- ACHE
- Library
- Guides
- Animal Research Resources
- Design of Experiments
Animal Research Resources: Design of Experiments
Websites
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AALAS Learning Library
Module on Design and Statistical Analysis of Laboratory Animal Studies.
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www.ASQ.org: What is Design of Experiments (DOE)?
Statistically based practical methods and tools for building in quality to any process.
Books
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The Design and Statistical Analysis of Animal Experiments
by
ISBN: 9781139344319Publication Date: 2014-03-05 -
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Peer-Reviewed Literature
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Considering Sex as a Biological Variable in Preclinical ResearchMiller LR, Marks C, Becker JB, Hurn PD, Chen WJ, Woodruff T, McCarthy MM, Sohrabji F, Schiebinger L, Wetherington CL, Makris S, Arnold AP, Einstein G, Miller VM, Sandberg K, Maier S, Cornelison TL, Clayton JA (2017). Considering sex as a biological variable in preclinical research. FASEB Journal, 31(1):29-34. doi:10.1096/fj.201600781R
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The Design and Statistical Analysis of Animal ExperimentsFesting MFW, The design and statistical analysis of animal experiments ILAR J 2002. 43(4): 191-3
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Guidelines for the Design and Statistical Analysis of Experiments Using Laboratory AnimalsFesting MFW, Altman DG. Guidelines for the design and statistical analysis of experiments using laboratory animals. ILAR J. 2002. 43(4): 244-256
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Improving Reproducibility in Animal Research by Splitting the Study Population into Several 'Mini-Experiments'von Kortzfleisch VT, Karp NA, Palme R, Kaiser S, Sachser N, Richter SH (2020). Improving reproducibility in animal research by splitting the study population into several 'mini-experiments'. Scientific Reports, 10(1):16579. doi: 10.1038/s41598-020-73503-4
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More Than 3Rs: the Importance of Scientific Validity for Harm-Benefit Analysis of Animal ResearchWürbel H (2017). More than 3Rs: the importance of scientific validity for harm-benefit analysis of animal research. Lab Animal, 46:164-167. doi.org/10.1038/laban.1220
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A Multi-Batch Design to Deliver Robust Estimates of Efficacy and Reduce Animal Use – a Syngeneic Tumour Case StudyKarp NA, Wilson Z, Stalker E, Mooney L, Lazic SE, Zhang B, Hardaker E (2020). A multi-batch design to deliver robust estimates of efficacy and reduce animal use - a syngeneic turmour case study. Scientific Reports, 10(1):6178. doi: 10.1038/s41598-020-62509-7
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Reduction of animal use: experimental design and quality of experimentsFesting MFW, Reduction of animal use: experimental design and quality of experiments. Laboratory Animals. 1994.28:212-221
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Reproducibility of Preclinical Animal Research Improves with Heterogeneity of Study SamplesVoelkl B, Vogt L, Sena ES, Würbel H (2018). Reproducibility of preclinical animal research improves with heterogeneity of study samples. PLoS Biology, 16(2):e2003693.
doi:10.1371/journal.pbio.2003693 -
Sex Bias in Preclinical Research and an Exploration of How to Change the Status QuoKarp NA, Reavey N (2019). Sex bias in preclinical research and an exploration of how to change the status quo. British Journal of Pharmacology, 176(21):4107-4118. doi 10.1111/bph.14539
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Sex Differences in Allometry for Phenotypic Traits in Mice Indicate That Females Are Not Scaled MalesWilson LAB, Zajitschek SRK, Lagisz M, Mason J, Haselimashhadi H, Nakagawa S (2022). Sex differences in allometry for phenotypic traits in mice indicate that females are not scaled males. Nature Communications, 13: 7502 doi.org/10.1038/s41467-022-35266-6
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Systematic Heterogenization for Better Reproducibility in Animal ExperimentationRichter H (2017). Systematic heterogenization for better reproducibility in animal experimentation. Lab Animal (NY), 46:343-349. doi: 10.1038/;abam/1330